The Sisterhood captures a candid look into the lives of devout yet fierce preachers' wives. Known as first ladies, these women work to ensure that their families and churches run as smoothly as possible. As wives of preachers in Atlanta, first ladies are held to high standards. But like everyone else, they experience struggles and triumphs. The show follows them as they navigate through marital troubles, financial issues, parenting challenges, personality conflicts and even demons from the past.