There's never a dull moment in the life of Sheen Estevez! After sneaking into his best friend Jimmy Neutron's laboratory and finding Jimmy's top-secret rocketship, Sheen accidentally blasts himself into outer space! 4 million and 1 light years away, Sheen crash-lands on Zeenu -- a strange planet inhabited by purple aliens called Zeenuians. After using their bathroom, Sheen wants to go home, but his rocketship got smashed in the crash and it's his only ride! No problemo, Sheen can totally fix it! All he needs to do is... uhh... where's Jimmy?
Meanwhile, an evil villain named Dorkus is super mad that Sheen destroyed his house in the crash, and he's bent on destroying the pesky Earth boy! Luckily, Sheen makes a ton of new friends on Zeenu, including Doppy (an alien who looks exactly like Sheen's old friend Carl Weezer), Emperor (the grand head ruler of Zeenu who thinks Sheen is a superior being sent from the heaven) and Nesmith (a talking chimp genius who's really good at things like math, English and fixing broken rockets). Will Sheen survive the evil plots of Dorkus and repair his rocket so he can get back to Earth before anyone notices he's gone?!? Watch and see!