Renee Rapp

Following her Jimmy Award win, Rapp was cast as Wendla in Theatre Charlotte's 2018 production of Spring Awakening. On July 27, 2018, Rapp performed at the 2018 Supergirl Pro Surf and Music Festival. On September 23, 2018, she took part in The Educational Theatre Foundation's fourth annual Broadway Back to School event held at Feinstein's/54 Below. In December 2018, she read for the role of Monteen in Roundabout Theatre Company's reading of Parade. On January 12, 2019, Rapp performed at BroadwayCon's 2019 Star to Be event, singing "They Just Keep Moving the Line" from NBC's Smash. She was next seen on March 4, 2019, performing at Feinstein's/54 Below's 54 Sings The High School Musical Trilogy, followed by their FOR THE GIRLS event on March 28.

On May 28, 2019, it was announced that Rapp would be taking over the role of Regina George in the Tony Award-nominated Broadway musical, Mean Girls, first for a limited run from June 7–26, then permanently starting September 10, 2019. On June 3, Rapp performed at The Green Room 42, singing songs from the show after an introduction by Tina Fey. The production closed on March 12, 2020, in accordance with Broadway's shutdown; it was later announced on January 7, 2021, that the show would not reopen.

On October 14, 2020, it was announced that Rapp had been cast as Leighton, one of the four leads in Mindy Kaling's HBO Max series The Sex Lives of College Girls.

On December 9, 2022, it was announced that Rapp would reprise her role as Regina George in a movie adaptation of the Mean Girls musical.