Rhea Perlman

Perlman began her acting career with a small role as an attendant in the off-off-Broadway play Dracula Sabbat, which ran from September 1970 to June 1971. In 1972, she played a bit role in the film Hot Dogs for Gauguin. That same year she appeared in Westbeth Playwrights Feminist Collective's production of Up – An Uppity Revue, along with her future husband, Danny DeVito.

One of her first notable parts was a recurring role on the television show Taxi as Zena, the sweet girlfriend of Louie De Palma (played by DeVito).

Following that, she had a role in a small play portraying a much tougher character. Producers Glen and Les Charles saw her in that play, which led to her landing the role as wisecracking barmaid Carla Tortelli on their sitcom Cheers in 1982. The series struggled with ratings in its first season, but by the time it ended in 1993, it was one of the most popular and successful shows of all time, winning 20 Emmy awards out of 95 nominations.

Perlman won the Emmy Award for Outstanding Supporting Actress in a Comedy four times: in 1984, 1985, 1986 and 1989. Over her 11 seasons on Cheers, she was nominated for an Emmy every year but 1992, becoming the Cheers star to have the most wins and nominations. She was also nominated for a Golden Globe for Best Supporting Actress six times, more than anyone else in that category. In 2011, CBS named Carla Tortelli as one of the greatest TV characters of all time.

In 1986, Perlman starred in an episode of Steven Spielberg's Amazing Stories titled "The Wedding Ring," which also starred DeVito as her character's husband.

In the 1990s, Perlman starred in several TV movies and motion pictures. In 1992, she starred in the made-for-TV-movie, To Grandmother's House We Go opposite Ashley Olsen and Mary-Kate Olsen, playing the wife of Jerry Van Dyke's character; the couple kidnapped the Olsen Twins' characters, hoping to cash in on ransom before Christmas. Other TV films in which she starred included the dramas A Place to Be Loved and In Spite of Love.

Perlman's motion picture roles included There Goes The Neighborhood (1992), Canadian Bacon (1995), Carpool (1996), Sunset Park (1996), and Matilda (1996). She had a cameo in the film 10 Items Or Less (2006), and also starred in the 2007 independent film Love Comes Lately.

In 1994, Perlman voiced 9-Eye in The Timekeeper, a Circle-Vision show at the Magic Kingdom in Tomorrowland. She later starred in the 1996 sitcom Pearl as the title character and was featured on the 2001 TV drama Kate Brasher. Among her notable guest appearances was on the fourth-season premiere of Becker, which starred Cheers co-star Ted Danson.

Perlman also appeared in a 2000 television film How to Marry a Billionaire: A Christmas Tale, in which she impersonated Jacqueline Kennedy. She also portrayed a therapist called Dr. Parella in the 2000 film Secret Cutting, which follows the story of a young girl named Dawn who self-injures. In 2007, Perlman appeared as Bertha in the West End of London in the comedy Boeing Boeing. In 2008, she starred in the Hallmark Channel original movie, The Christmas Choir, and appeared in Beethoven's Big Break in 2008 as Patricia Benji. In 2009, she appeared as Tanya's mother on the series Hung for Home Box Office Networks. In 2011, Perlman had a guest appearance as Mittens in one episode of Wilfred.

In 2009, Perlman and her daughter Lucy DeVito starred in the off-Broadway play Love, Loss, and What I Wore, adapted by Nora and Delia Ephron, at the Westside Theatre.

From 2014 to 2017, she starred in a recurring role on The Mindy Project as Danny's mother, Annette Castellano.

In 2023, Perlman earned critical praise for playing Barbie creator Ruth Handler in Greta Gerwig's film Barbie.