Louisa Jacobson

On stage, Jacobson made her professional acting debut as Mary Dalton in Yale Repertory Theatre's production of Nambi E. Kelley's Native Son, directed by Seret Scott in 2017. The following year she starred in Williamstown Theatre Festival's production of Carson McCullers' play Member of the Wedding (2018), opposite Tavi Gevinson and directed by Gaye Taylor Upchurch. In 2019, she starred as Juliet in The Old Globe's production of Romeo and Juliet. The Times of San Diego praised her performance writing, "Jacobson has the pulsating impetuosity of a teenager...Her profligate joy in love and unchecked anguish in bereavement are palpable, visceral".

In 2022 she acted in the Lindsay Joelle play Trayf at the Geffen Playhouse. Though only in one scene, critics praised her for stealing the show. Maureen Lee Lenker of Entertainment Weekly wrote, "Jacobson makes a meal of her featured role" and that "She's heartbreaking in her single scene, confronting Shmuel about the constraints of their religion." Also in 2022, she made her television debut starring in Julian Fellowes' HBO period drama series The Gilded Age acting opposite Carrie Coon, Christine Baranski, Cynthia Nixon and Denée Benton. In 2023 she was nominated alongside the cast for the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series.

In 2024, Jacobson served as the assistant director to Michael Breslin for the Off-Broadway play Invasive Species. That same year she was cast in a supporting role Celine Song's A24 romantic comedy Materialists which is filming in New York City.