Keams was born on August 19, 1951, in Flagstaff, Arizona. She was raised on the Navajo reservation then went to the University of Arizona, where she studied drama and film.
After graduating from college, Keams moved to New York City to pursue theater. In New York, she wrote and performed with Hanay Geiogamah's (Kiowa/Delaware) Native American Theater Ensemble at La MaMa Experimental Theatre Club. She adapted a Navajo creation story for the 1972 production Na Haaz Zan and also performed in Geiogamah's Body Indian. The ensemble took both pieces on tour in 1972 and 1973, performing at the University of New Mexico, the College of Santa Fe, Haskell Indian Junior College, the Walker Art Center, the American Indian Center in Chicago, the Smithsonian Institution, Rough Rock Demonstration School in Chinle, Arizona, Springfield College, the University of Massachusetts Amherst, the University of Michigan, the University of Wisconsin - Milwaukee, Dartmouth College, and the University at Buffalo, among other places.
Keams made her film debut playing Little Moonlight in Clint Eastwood's western The Outlaw Josey Wales (1976).
In 2021, she had a recurring role in the Peacock sitcom Rutherford Falls, about relationships between a fictional Native American tribe and the New England town it borders. Showrunner Sierra Teller Ornelas described Keams as "Navajo royalty", saying, "When she walked on the set, I was starstruck".
In addition to her film work, Keams gives live performances and workshops. She is a resident artist at the Los Angeles Music Center. Keams currently resides in Pasadena, California.
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