Vance started his career on the Broadway stage in Fences, Six Degrees of Separation, and Lucky Guy for which he won a Tony Award for Best Featured Actor in a Play.[2] He is known for his roles in films such as Hamburger Hill (1987), The Hunt for Red October (1990), The Preacher's Wife (1996), Cookie's Fortune (1999), and Isle of Dogs (2018).
Vance is also known for work on television on shows such as Law & Order: Criminal Intent, where he played Assistant District Attorney Ron Carver. He also guest-starred on Law & Order, Picket Fences, The Closer, Revenge, Scandal, and Masters of Sex. Vance won great acclaim for his performance as Johnnie Cochran in the FX limited series The People v. O. J. Simpson: American Crime Story for which he received the Primetime Emmy Award for Outstanding Lead Actor in a Limited Series or Movie. He recently appeared in the HBO television film The Immortal Life of Henrietta Lacks (2017) and HBO's Lovecraft Country (2020).
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