Andoh was a member of the BBC's Radio Drama Company. Her television credits include Casualty (she played Colette Griffiths (née Kierney) from 2000 until 2003), Jonathan Creek, EastEnders (where she played jazz singer Karen, the lodger of Rachel Kominski in 1991), and The Tomorrow People (where she played Amanda James in the story The Rameses Connection in 1995).
She has appeared in Doctor Who a number of times: in 2006 as Sister Jatt in series 2 episode "New Earth" and as Nurse Albertine in the audio drama Year of the Pig. In 2007, she appeared in several episodes of the third series ("Smith and Jones", "The Lazarus Experiment", "42", "The Sound of Drums", and "Last of the Time Lords") as Francine Jones, the mother of Martha Jones (Freema Agyeman). She reprised her role in the finale of series 4 ("The Stolen Earth" and "Journey's End"). Andoh's other television work includes playing the head of M.I.9 in Series 3 to Series 5 of M.I. High and D.C.I. Ford in Missing. In the American streaming television drama series Bridgerton (2020) she plays Lady Danbury. She played the guest role of Mother Nenneke in the second season of the Polish - American fantasy drama streaming television series The Witcher (2021). In April 2023, The Real Crown: Inside the House of Windsor, an ITV television documentary series on the British royal family, aired. Andoh narrates the series.
She narrated one audio book version of Alexander McCall Smith's The No. 1 Ladies' Detective Agency series of detective novels and Ann Leckie's Imperial Radch Series trilogy (although not all of the US editions), as well as Julia Jarman's children's books, The Jessame Stories and More Jessame Stories. She also narrated the audio book version of Nnedi Okorafor's novel Lagoon with Ben Onwukwe, and Chimamanda Ngozi Adichie's Americanah. She narrated The Power by Naomi Alderman, former President Barack Obama’s favorite book of 2017. Her career in audio dramas has included the Voice of Planet B in the science fiction series Planet B on BBC Radio 7. In 2004, she was cast in the video game Fable. In 2017 she provided the voice of war chief Sona in the video game Horizon Zero Dawn.
In film, Andoh appeared in Noel Clarke's 2008 film Adulthood and its 2016 sequel Brotherhood as the mother of Clarke's character, Sam Peel. She played Chief of Staff Brenda Mazibuko opposite Morgan Freeman's Nelson Mandela in Clint Eastwood's 2009 drama film Invictus.
Andoh has worked extensively in the theatre. Her credits include His Dark Materials, Stuff Happens and The Revenger's Tragedy at the National Theatre; A Streetcar Named Desire (National Theatre Studio); Troilus and Cressida, Julius Caesar, Tamburlaine and The Odyssey (RSC); Sugar Mummies and Breath Boom (Royal Court); Richard II (Globe); Les Liaisons Dangereuses (Donmar Warehouse); Great Expectations (Bristol Old Vic); Blood Wedding (Almeida); Nights at the Circus, The Dispute and Pericles (Lyric Hammersmith); Julius Caesar (The Bridge); Purgatorio (Arcola); The Vagina Monologues (Criterion); Starstruck (Tricycle) and In The Red and Brown Water (Young Vic).
Adjoa Andoh has not appeared on Broadway.
Adjoa Andoh has appeared on London's West End in 2 shows.
Adjoa Andoh's first West End show was Les Liasons Dangereuses which opened in 2015
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