Fresh off his Emmy Award win, Bob Newhart returns to The Big Bang Theory as Professor Proton, Sheldon's favorite childhood hero. In the episode, when Professor Proton (Newhart) contacts Leonard (Johnny Galecki) to ask for help with an experiment, a scorned Sheldon (Jim Parsons) seeks Revenge by befriending a rival science TV host, Bill Nye.
Leonard and Sheldon are brilliant physicists - geniuses in the laboratory, but socially challenged everywhere else. Enter beautiful, street-smart neighbor, Penny, who aims to teach them a thing or two about life. Despite their on-again, off-again relationship in the past, Leonard believes he's found true love with Penny. Even Sheldon has found a female companion, entering into a "Relationship Agreement" with neurobiologist Amy Farrah Fowler. In their free time, Leonard and Sheldon continue to enjoy frequent trips to the comic book store and fantasy role-playing games with their ever-expanding universe of friends, including fellow scientists Koothrappali, Wolowitz and Wolowitz's adorable microbiologist wife, Bernadette.
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