Ryan Murphy Reveals Only 4 SCREAM QUEENS Characters Will Survive the Season

Ryan Murphy's highly anticipated horror anthology series SCREAM QUEENS features a cast of Hollywood A-listers, including Emma Roberts, Jamie Lee Curtis, Lea Michelle, Ariana Grande and Nick Jonas. Unfortunately for the characters they portray, most of them will not be present when the Season Finale rolls around. During a group interview, the 'Glee' scribe revealed to Zap2it, "Only four of them live."

In addition, Murphy shared that unlike his FX anthology series "American Horror Story," in which the same actors return as different characters in future installments, that will not be the case with his newest project. "If you're dead, you're dead and only four of them live," Murphy says. "The second season is the four remaining survivors playing the same characters going to a new 'Scream Queens' venue. Then we bring in other people and the death party starts again."

Murphy went on to tease that additional guest stars, including some female icons of the horror genre, are on tap for the show. "We're slowly starting to go out to the great women of horror and also the great guys of horror and be like, 'Come in our playground. Please do an episode or two,'" he shared. "So far we have some great secrets of our sleeve. People [say] yes because of Jamie Lee."

SCREAM QUEENS premieres September 22 on FOX.

Watch the full trailer below:

Award-winning executive producers Ryan Murphy (GLEE, "American Horror Story"), Brad Falchuk (GLEE, "American Horror Story") and Ian Brennan (GLEE) meld comedy, mystery and horror in SCREAM QUEENS. All hell is about to break loose for the Kappa House sisters of Wallace University when a murder takes place, exactly 20 years after a mysterious death originally rocked their college campus.

The super-charged anthology series is a modern take on the classic whodunit with a killer cast, including Emma Roberts ("American Horror Story: Freak Show," "Scream 4"), Jamie Lee Curtis ("Halloween," "A Fish Called Wanda," "True Lies"), Lea Michele (GLEE), Oliver Hudson ("Nashville," "Rules of Engagement"), Keke Palmer ("Akeela and the Bee," "Masters of Sex") and guest stars Ariana Grande and Nick Jonas ("Kingdom"), among others. With at least one casualty each week until the mystery is solved, anyone could be the next victim - or the murderer.